Molecular Characterization: CD63(Ala103-Val203) hFc(Glu99-Ala330)Molecular weight: The protein has a predicted molecular mass of 37.7 kDa after removal of the signal peptide. The apparent molecular mass of CD63-hFc is approximately 35-55 kDa due to glycosylation.Description: Recombinant human CD63 protein with C-terminal human Fc tagThe protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
