Molecular Characterization: CLDN6(138-160)(Trp138-Leu160) hFc(Glu99-Ala330)Molecular weight: The protein has a predicted molecular mass of 28.9 kDa after removal of the signal peptide. The apparent molecular mass of CLDN6(138-160)-hFc is approximately 25-35 kDa due to glycosylation.Description: Recombinant Human CLDN6(138-160) Protein with C-terminal human Fc tagTight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
