Recombinant Hepatitis C Virus NS5B (2634-2752 a.a)
Biozol Catalog Number:
ABI-32-5481
Supplier Catalog Number:
32-5481
Alternative Catalog Number:
ABI-32-5481-10UG
Manufacturer:
Abeomics
Category:
Proteine/Peptide
Source : Escherichia Coli. Recombinant Hepatitis C Virus NS5B produced in E. coli is a single polypeptide chain containing 155 amino acids (aa 2634-2752) and having a molecular mass of 17kDa (NCBI Accession NP_671491).Recombinant HCV NS5B is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the hosts immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).
Purity:
Greater than 90% as determined by SDS-PAGE.
Antibody Type:
Recombinant Antibody
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