Recombinant Human Cyclin-Dependent Kinase Inhibitor 1/CDKN1A/p21 (C-6His)

Product Overview

• Article Name: Recombinant Human Cyclin-Dependent Kinase Inhibitor 1/CDKN1A/p21 (C-6His)
• Biozol Catalog Number: ABI-32-8095
• Supplier Catalog Number: 32-8095
• Alternative Catalog Number: ABI-32-8095-50UG
• Manufacturer: Abeomics
• Category: Proteine/Peptide

Product Description

Source: E.coli. MW :19.25kD. Recombinant Human p21 Cyclin Dependent Kinase 4 Inhibitor 1A is produced by our E.coli expression system and the target gene encoding Ser2-Pro164 is expressed with a 6His tag at the C-terminus. Cyclin-Dependent Kinase Inhibitor 1 (CDKN1A) is a member of the CDI family. CDKN1A is widely expressed in all adult tissues, but low expressed in the brain tissue. CDKN1A can be induced by p53/TP53, mezerein and IFNB1, repressed by HDAC1. CDKN1A may be an important intermediate, by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage, CDKN1A can bind to and inhibit cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.

Product Properties

• NCBI: 1026
• UniProt: P38936

Application Notes

• Application Dilute: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freez