Recombinant Human Isocitrate Dehydrogenase 1/IDH1 (R132H, C-8His)
Biozol Catalog Number:
ABI-32-8701-10
Supplier Catalog Number:
32-8701-10
Alternative Catalog Number:
ABI-32-8701-10-10UG
Manufacturer:
Abeomics
Category:
Proteine/Peptide
Source: E.coli. MW :48.1kD. Recombinant Human Isocitrate Dehydrogenase is produced by our E.coli expression system and the target gene encoding Met1-Leu414 is expressed with a 8His tag at the C-terminus. Isocitrate Dehydrogenase [NADP] Cytoplasmic (IDH1) belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 exists as a homodimer, binding one magnesium or manganese ion per subunit. Mutations of IDH1 have been shown to cause metaphyseal chondromatosis with aciduria and are involved in the development of glioma. IDH plays a role in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the a-hydroxylation of phytanic acid.
