Source: E.coli. MW :112.9kD. Recombinant E.coli Beta-galactosidase(M443L, C500S) is produced by our E.coli expression system and the target gene encoding Met1-Lys1024(12-41AA deletion) is expressed. beta-galactosidase is an exoglycosidase which hydrolyzes the beta-glycosidic bond formed between a galactose and its organic moiety. It may also cleave fucosides and arabinosides but with much lower efficiency. beta-galactosides include carbohydrates containing galactose where the glycosidic bond lies above the galactose molecule. Substrates of different beta-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins. It is an essential enzyme in the human body. Deficiencies in the protein can result in galactosialidosis or Morquio B syndrome. In E. coli, the gene of beta-galactosidase, the lacZ gene, is present as part of the inducible system lac operon which is activated in the presence of lactose when glucose level is low. beta-galactosidase is important for organisms as it is a key provider in the production of energy and a source of carbons through the break down of lactose to galactose and glucose.
