Biotinylated Recombinant Human Cadherin-1/E-cadherin/CDH1 (C-His)
Biozol Catalog Number:
ABI-32-9121-250
Supplier Catalog Number:
32-9121-250
Alternative Catalog Number:
ABI-32-9121-250-250UG
Manufacturer:
Abeomics
Category:
Proteine/Peptide
Alternative Names:
Cadherin-1, CDH1, CAM 120/80, E-cadherin, CD324
Source : Human 293 Cells,E-Cadherin is a calcium-dependent cell adhesion glycoprotein that belongs to the cadherin family. E-Cadherin is expressed in non-neural epithelial tissues. It tends to interact with each other in a homophilic manner in connecting cells. E-Cadherin clusters are critical components of adherent junctions between epithelial cells and act in the formation and maintenance of the epithelial cell barrier. E-Cadherin is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. E-Cadherin loss contributes to cancer metastasis. The extracellular E-Cadherin N-terminal domain can be cleaved by several proteases and is released as a soluble factor that enhances cancer cell motility and EGFR-dependent survival and proliferation.
Antibody Type:
Recombinant Antibody
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