Source : Human 293 Cells,IL-2RB, also known as interleukin-2 receptor subunit beta, is the receptor for interleukin-2, which plays a role in regulating normal lymphocyte development. IL-2RB expression was restricted to the earliest B22+ cells (CD43+CD24-, prepro B cells, fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. IL2 receptor complex facilitates the receptor-mediated endocytosis and transduces the mitogenic signals of IL2. IL-2RB is the subunit that is critical for receptor-mediated signaling via physically or functionally coupling to other signaling molecules, such as the Jak-STAT and Src-family protein tyrosine kinase.
Antibody Type:
Recombinant Antibody
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