Recombinant Human Platelet-derived Growth Factor Receptor/PDGF Ralpha (C-6His)
Biozol Catalog Number:
ABI-32-9299-500
Supplier Catalog Number:
32-9299-500
Alternative Catalog Number:
ABI-32-9299-500-500UG
Manufacturer:
Abeomics
Category:
Proteine/Peptide
Alternative Names:
Platelet-derived growth factor receptor alpha, PDGFR-alpha, Alpha platelet-derived growth factor receptor,CD140 antigen-like family member A, Platelet-derived growth factor alpha receptor, Platelet-derived growth factor receptor 2, PDGFR-2, CD140a
Source : Human Cells,Platelet-derived Growth Factor Receptor Alpha (PDGF R-Alpha) is an enzyme that belongs to the class III subfamily of receptor tyrosine kinases.It is a type I transmembrane glycoprotein, and can form homo- or hetero-dimeric receptors when engaged by dimers of the PDGF family of growth factors, PDGF R-Alpha is strongly expressed in oligodendrocyte, lung, skin and intestinal progenitor cells and induced by inflammation or growth in culture, but is lowly expressed in most mesenchymal cells. PDGF R-Alpha autophosphorylates upon dimerization, activating signaling cascades in PI-3kinase Ras-MAP kinase, and PLC-gamma pathways. PDGF R-Alpha has infulence on local gradients of epithelially produced PDGF-AA or PDGF-CC during formation of the cranial ,cardiac neural crest and interstitial kidney mesenchyme.
Antibody Type:
Recombinant Antibody
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