Recombinant Human BMP Receptor II/BMPR2/PPH1 (C-Fc-6His)
Biozol Catalog Number:
ABI-32-9672-500
Supplier Catalog Number:
32-9672-500
Alternative Catalog Number:
ABI-32-9672-500-500UG
Manufacturer:
Abeomics
Category:
Proteine/Peptide
Alternative Names:
Bone Morphogenetic Protein Receptor Type-2, BMP Type-2 Receptor, BMPR-2, Bone Morphogenetic Protein Receptor Type II, BMP Type II Receptor, BMPR-II, BMPR2, PPH1
Source : Human Cells,Bone Morphogenetic Protein Receptor II (BMPR-II) is a Type II Serine/Threonine Kinase that mediates cellular responses to BMPs. BMPR-II is characterized by lacking of a GS domain, and presence of a C-terminal extension typical of type II receptors. BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. BMPR-II plays a key role in cell growth. Defects in BMPR-II have been linked to primary pulmonary hypertension. Human and mouse BMPR-II are highly conserved and share 97 % amino acid sequence identity.
Antibody Type:
Recombinant Antibody
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