Polyclonal Antibody to MEF2A (Phospho-Thr312), Rabbit
Biozol Catalog Number:
ABI-35-1038-50
Supplier Catalog Number:
35-1038-50
Alternative Catalog Number:
ABI-35-1038-50-50UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
IF, IHC, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Peptide sequence around phosphorylation site of threonine 312 (L-A-T(p)-P-V) derived from Human MEF2A.
Alternative Names:
MEF2||ADCAD1||RSRFC4||RSRFC9
The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes agamous and deficiens and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain .
