Polyclonal Antibody to CREB (Phospho-Ser133), Rabbit
Biozol Catalog Number:
ABI-35-1051
Supplier Catalog Number:
35-1051
Alternative Catalog Number:
ABI-35-1051-100UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Peptide sequence around phosphorylation site of serine 133 (R-P-S(p)-Y-R) derived from Human CREB.
Alternative Names:
CREB-1|| CREB1
CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34 . It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories . Xing J, et al. (1998) Mol Cell Biol 18(4): 1946-55. Tan Y, et al. (1996) EMBO J, 15(17): 4629-42. Hao, M. et al. (1996) J. Biol. Chem. 271, 29380-29385. Mayo LD, et al. (2001) Biol Chem, 276(27): 25184-9.
