Polyclonal Antibody to Tau (Phospho-Ser404), Rabbit

Catalog Number: ABI-35-1109
Article Name: Polyclonal Antibody to Tau (Phospho-Ser404), Rabbit
Biozol Catalog Number: ABI-35-1109
Supplier Catalog Number: 35-1109
Alternative Catalog Number: ABI-35-1109-100UL
Manufacturer: Abeomics
Host: Rabbit
Category: Antikörper
Application: IF, IHC, WB
Species Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around phosphorylation site of serine 404 (D-T-S(p)-P-R) derived from Human Tau.
Alternative Names: MAPT|| MTAPT|| MTBT1|| Neurofibrillary tangle protein|| PHF-tau
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Li G, Yin H, et.al .(2004) J Biol Chem , 279(16): 15938-45. Noble W, et al. (2003) Neuron , 38(4): 555-65. Giasson BI, et al.(2002). Biochemistry, 41(51): 15376-87. Lee G., et.al. (1989). Neuron 2:1615-1624. Andreadis A.et.al. (1992) Biochemistry 31:10626-10633.
Clonality: Polyclonal
NCBI: 4137
UniProt: P10636
Form: Purified
Target: Tau (Phospho-Ser404)
Application Dilute: Predicted MW: 48 62 78 kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200