Polyclonal Antibody to FKHR (Phospho-Ser319), Rabbit
Biozol Catalog Number:
ABI-35-1131
Supplier Catalog Number:
35-1131
Alternative Catalog Number:
ABI-35-1131-100UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
IF, IHC, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Peptide sequence around phosphorylation site of serine 319 (T-S-S(p)-N-A) derived from Human FKHR/FOXO1A.
Alternative Names:
FOXO1
FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14 Rena G, et al. (2002) EMBO J 21(9): 2263-2271. Woods YL, et al. (2001) Biochem J355(Pt 3): 597-607. Rena G, et al. (2001) Biochem J 354(Pt 3): 605-612.
