Polyclonal Antibody to PKCbeta (Phospho-Thr641), Rabbit
Biozol Catalog Number:
ABI-35-1163
Supplier Catalog Number:
35-1163
Alternative Catalog Number:
ABI-35-1163-100UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
IF, IHC, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Peptide sequence around phosphorylation site of threonine 641 (E-L-T(p)-P-T) derived from Human PKCb
Alternative Names:
PKCB|| PRKCB1|| PRKCB2
Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at Ser-559, Ser-644 and Ser-652, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates Ser-36 of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of Thr-6 of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 Lys-4 (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters. Zhang Y, et al. (2006) Mol Cell Biol , 26: 6748-6761 Castoria G, et al. (2004) Mol Cell Biol , 24: 7643-7653 Marcil J, et al. (1999) Biochem J , 337:185-192 Bornancin F, et al. (1996) Curr Biol , 6:1114-1123.
