Polyclonal Antibody to Merlin (Phospho-Ser518), Rabbit

Product Overview

• Article Name: Polyclonal Antibody to Merlin (Phospho-Ser518), Rabbit
• Biozol Catalog Number: ABI-35-1245-50
• Supplier Catalog Number: 35-1245-50
• Alternative Catalog Number: ABI-35-1245-50-50UL
• Manufacturer: Abeomics
• Host: Rabbit
• Category: Antikörper
• Application: IF, WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Peptide sequence around phosphorylation site of serine 518 (R-L-S(p)-M-E) derived from Human Merlin.
• Alternative Names: MERL|| NF2|| Neurofibromin 2|| SCH|| Schwannomerlin

Product Description

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Guang-Hui Xiao, et al. (2005) Mol. Cell. Biol , 25: 2384 - 2394. Hi-Su Yang, et al. (2006) Cancer Res , 66: 2708 - 2715. R Bohni, et al. (1994) J. Biol. Chem , 269: 14541 - 14545. Adam J. Ratner, et al. (2001) J. Biol. Chem , 276: 19267 - 19275.

Product Properties

• Clonality: Polyclonal
• NCBI: 4771
• UniProt: P35240
• Form: Purified
• Target: Merlin (Phospho-Ser518)

Application Notes

• Application Dilute: Predicted MW: 69kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200