Polyclonal Antibody to Histone H2A.X (Phospho-Ser139), Rabbit
Biozol Catalog Number:
ABI-35-1247-50
Supplier Catalog Number:
35-1247-50
Alternative Catalog Number:
ABI-35-1247-50-50UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
IF, WB
Species Reactivity:
Human
Immunogen:
Peptide sequence around phosphorylation site of serine 139 (Q-A-S(p)-Q-E) derived from Human Histone H2A.X.
Alternative Names:
H2A.X|| H2AFX|| H2a/x|| HIST5-2AX
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. Yaneva M, et al. (2005) Nucleic Acids Res. 33(16): 5320-5330. Tsukuda T, et al.(2006) Nature. Author manuscript, available in PMC 2006 March 6.
