Polyclonal Antibody to PKR (Phospho-Thr451), Rabbit
Biozol Catalog Number:
ABI-35-1264
Supplier Catalog Number:
35-1264
Alternative Catalog Number:
ABI-35-1264-100UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
IHC
Species Reactivity:
Human
Immunogen:
Peptide sequence around phosphorylation site of threonine 451 (K-G-T(p)-L-R) derived from Human PKR.
Alternative Names:
ADRB2|| E2AK2|| EIF2AK2|| EIF2aK|| PRKR
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. Ingrid K. Ruf, et,al. (2005) J. Virol , 79: 14562 - 14569. Christy M. Hebner,et,al. (2006) J. Gen. Virol , 87: 3183 - 3193. Rika van Huizen, et,al. (2003) J. Biol. Chem , 278: 15558 - 15564.
