Polyclonal Antibody to GSK3 Alpha/beta(Phospho-Tyr279/216), Rabbit

Product Overview

• Article Name: Polyclonal Antibody to GSK3 Alpha/beta(Phospho-Tyr279/216), Rabbit
• Biozol Catalog Number: ABI-35-1272
• Supplier Catalog Number: 35-1272
• Alternative Catalog Number: ABI-35-1272-100UL
• Manufacturer: Abeomics
• Host: Rabbit
• Category: Antikörper
• Application: IF, IHC, WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Peptide sequence around phosphorylation site of tyrosine 279/216 (V-S-Y(p)-I-C) derived from Human GSK3 alpha/beta.
• Alternative Names: Factor A|| GSK-3 alpha/beta|| kinase GSK3-alpha/beta

Product Description

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13, 137(1-2): 193-201 Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02, 316(2): 411-415 Fan G, et al. J Biol Chem 2003 Dec 26, 278(52): 52432-52436 Liao X, et al. Mol Cancer Ther 2003 Nov, 2(11): 1215-1222

Product Properties

• Clonality: Polyclonal
• NCBI: 2931
• UniProt: P49840
• Form: Purified
• Target: GSK3 Alpha/ Beta(Phospho-Tyr279/216)

Application Notes

• Application Dilute: Predicted MW: 46, 51kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200