Polyclonal Antibody to Aurora A (phospho-Thr288), Rabbit
Biozol Catalog Number:
ABI-35-1313
Supplier Catalog Number:
35-1313
Alternative Catalog Number:
ABI-35-1313-100UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Human, Mouse
Immunogen:
Peptide sequence around phosphorylation site of threonine 288 (R-T-T(p)-L-M) derived from Human Aurora A.
Alternative Names:
AIK|| ARK1|| AURA|| BTAK|| STK6
Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity By similarity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Bischoff, J.R. et al. (1998) EMBO J 17, 3052-65. Hauf, S. et al. (2003) J Cell Biol 161, 281-94. Walter, A.O. et al. (2000) Oncogene 19, 4906-16. Zhou, H. et al. (1998) Nat Genet 20, 189-93.
