Polyclonal Antibody to Stat2 (phospho-Tyr690), Rabbit
Biozol Catalog Number:
ABI-35-1319-50
Supplier Catalog Number:
35-1319-50
Alternative Catalog Number:
ABI-35-1319-50-50UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
WB
Species Reactivity:
Human
Immunogen:
Peptide sequence around phosphorylation site of tyrosine 690 (R-K-Y(p)-L-K)derived from Human Stat2
Alternative Names:
P113|| ISGF-3|| STAT113|| MGC59816
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.
