Polyclonal Antibody to FAK (phospho-Tyr576/Tyr577), Rabbit
Biozol Catalog Number:
ABI-35-1327
Supplier Catalog Number:
35-1327
Alternative Catalog Number:
ABI-35-1327-100UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
IF, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Peptide sequence around phosphorylation site of tyrosine 576/tyrosine 577 (S-T-Y(p)-Y(p)-K-A) derived from Human FAK.
Alternative Names:
FADK 1|| FAK1|| PTK2
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. Parsons, J.T. et al. (2000) Oncogene 19, 5606-5613 Schaller, M.D. et al. (1994) Mol. Cell. Biol. 14, 1680-1688. Cobb, B.S. et al. (1994) Mol. Cell. Biol. 14, 147-155. Chen, H.C. et al. (1996) J. Biol. Chem. 271, 26329-26334.
