Anti-Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Monoclonal Antibody(Clone: TYRP1/1986), Clone: [TYRP1/1986], Mouse

Product Overview

• Article Name: Anti-Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Monoclonal Antibody(Clone: TYRP1/1986), Clone: [TYRP1/1986], Mouse
• Biozol Catalog Number: ABI-36-3335
• Supplier Catalog Number: 36-3335
• Alternative Catalog Number: ABI-36-3335-100UG
• Manufacturer: Abeomics
• Host: Mouse
• Category: Antikörper
• Application: ELISA, IHC
• Species Reactivity: Human
• Immunogen: A recombinant fragment (around aa 257-377) of human TYRP1 protein (exact sequence is proprietary)
• Alternative Names: 5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75

Product Description

It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence sµggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [TYRP1/1986]
• NCBI: 7306
• UniProt: P17643

Application Notes

• Application Dilute: ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA), ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95