Anti-Cyclin E (G1/S-Phase Cyclin) Monoclonal Antibody(Clone: CCNE1/2460), Clone: [CCNE1/2460], Mouse

Product Overview

• Article Name: Anti-Cyclin E (G1/S-Phase Cyclin) Monoclonal Antibody(Clone: CCNE1/2460), Clone: [CCNE1/2460], Mouse
• Biozol Catalog Number: ABI-36-3448
• Supplier Catalog Number: 36-3448
• Alternative Catalog Number: ABI-36-3448-100UG
• Manufacturer: Abeomics
• Host: Mouse
• Category: Antikörper
• Application: FACS, IF, IHC, WB
• Species Reactivity: Human
• Immunogen: Recombinant human Cyclin E (CCNE1) protein fragment (around aa 10-176) (exact sequence is proprietary)
• Alternative Names: CCNE1, Cyclin E1, G1/S-specific cyclin-E1

Product Description

Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress throµgh S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [CCNE1/2460]
• NCBI: 898
• UniProt: P24864

Application Notes

• Application Dilute: Flow Cytometry (1-2ug/million cells), Immunofluorescence (1-2ug/ml), Western Blot (1-2ug/ml), ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM