Anti-Major Vault Protein (MVP) Monoclonal Antibody(Clone: 1014), Clone: [1014], Mouse
Biozol Catalog Number:
ABI-36-3670-20
Supplier Catalog Number:
36-3670-20
Alternative Catalog Number:
ABI-36-3670-20-20UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
FACS, IF
Species Reactivity:
Human
Immunogen:
proteins precipitated from human breast cancer MCF-7 cells
Alternative Names:
Lung resistance-related protein (LRP), Major Vault Protein, MVP, VAULT1
Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for 70% of their mass. Their shape is reminiscent of the nucleopore central plµg. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
