Anti-Major Vault Protein (MVP) Monoclonal Antibody(Clone: VP2897R), Clone: [VP2897R], Rabbit

Product Overview

• Article Name: Anti-Major Vault Protein (MVP) Monoclonal Antibody(Clone: VP2897R), Clone: [VP2897R], Rabbit
• Biozol Catalog Number: ABI-36-3671
• Supplier Catalog Number: 36-3671
• Alternative Catalog Number: ABI-36-3671-100UG
• Manufacturer: Abeomics
• Host: Rabbit
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant full-length human MVP protein
• Alternative Names: Lung resistance-related protein (LRP), Major Vault Protein, MVP, VAULT1

Product Description

Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for 70% of their mass. Their shape is reminiscent of the nucleopore central plµg. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [VP2897R]
• NCBI: 9961
• UniProt: Q14764

Application Notes

• Application Dilute: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes),