CD Mouse spleen and bone marrow cells enriched for NK-1+ cells
Alternative Names:
CD161 antigen-like family member C, CD161c, Killer cell lectin-like receptor subfamily B member 1C (Klrb1c), Klrb1f, Lymphocyte antigen 55c (Ly55c), Lymphocyte antigen 59, Natural killer cell surface protein P1-40, NK1.1, NKR-P1 40, NKR-P1.9, NKR-P1C, NKRP1
NK1.1 is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by theKlrb1c/NKR-P1Cgene.It is predominantly expressed as a disulfide-linked homodimer on NK cells however, it is also expressed on NK-T cells, a rare population of T lymphocytes.NK1.1 is expressed in some Mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cellsin vitroand rejection of bone marrow allograftsin vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN- production, and cytotoxic granule release. NK-1.1 is commonly used as a Mouse NK cell marker.
