Anti-Clostridium difficile (Toxin A) Monoclonal Antibody(Clone: 253/422), Clone: [253/422], Mouse
Biozol Catalog Number:
ABI-36-3704-20
Supplier Catalog Number:
36-3704-20
Alternative Catalog Number:
ABI-36-3704-20-20UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
ELISA, IF
Immunogen:
C. difficile Toxin A
Alternative Names:
Clostridium difficile, C. difficile, tcdA, toxA
This MAb reacts with C. difficile Toxin A, but not with Cholera subunit a, Cholera toxin, Pseudomonas aerµginosa exotoxin A, H-LT, P-LT. Clostridium difficile is a major nosocomial pathogen that causes antibiotic- associated colitis. Clostridium difficile mediates inflammatory diarrhea by releasing two large protein enterotoxins (Toxin A and Toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. Clostridium difficile Toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. Clostridium difficile Toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21, leading to cytochrome c release and caspase-3 activation throµgh Bak activation.
