Source : HEK293 Cells As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-alpha, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
Purity:
> 97 % as determined by SDS-PAGE
Antibody Type:
Recombinant Antibody
Application Dilute:
Measured by its binding ability in a functional ELISA. Immobilized recombinant human EGF at 10 µg/ml (100 µL/well) can bind human EGFR with a linear range of 0.64-400 ng/ml. Endotoxin :< 1.0 EU per µg of the protein as determined by the LAL method. Oth
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