E. coli-derived rat IL3 recombinant protein (Position: S28-C166). Rat IL3 shares 32% and 55% amino acid (aa) sequence identity with human and mouse IL3, respectively.
Interleukin 3, also known as IL-3, is a protein that in humans is encoded by the IL3 gene. It is mapped to 5q31.1. IL-3 is an interleukin, a type of biological signal (cytokine) that can improve the bodys natural response to disease as part of the immune system. It acts by binding to the interleukin-3 receptor. IL-3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the addition of IL-7, into lymphoid progenitor cells. In addition, IL-3 stimulates proliferation of all cells in the myeloid lineage (granulocytes, monocytes, and dendritic cells), in conjunction with other cytokines, e.g., Erythropoietin (EPO), Granulocyte macrophage colony-stimulating factor (GM-CSF), and IL-6. IL-3 is secreted by basophils and activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response.
Figure 1: Anti-IL-3 antibody(39-2002) . Western blotting : Lanes: Anti IL-3(39-2002) at 0.5ug/ml. WB: Recombinant Rat IL-3 Protein 0.5ng. Predicted band size: 15 kDa.Observed band size: 15 kDa.
Figure 2: Anti- IL-3 antibody(39-2002). Western blotting : - Lanes: Anti IL-3(39-2002) at 0.5ug/ml, Lane 1: PC-12 Whole Cell Lysate at 40ug, Lane 2: NRK Whole Cell Lysate at 40ug, Lane 3: RH35 Whole Cell Lysate at 40ug, Predicted band size: 17 kDa: Observed band size: 37 kDa.
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