Human Akt1 Protein, His,Strep II Tag, Unconjugated
Biozol Catalog Number:
ABS-AK1-H5283-500UG
Supplier Catalog Number:
AK1-H5283-500ug
Alternative Catalog Number:
ABS-AK1-H5283-500UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
RACalpha serine/threonineprotein kinase (AKT1) is also known PKB, Protein kinase B alpha, PKB alpha, Protooncogene cAkt and RACPKalpha, which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and RAC subfamily and is expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). AKT1 is one of 3 closely related serine/threonineprotein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT is responsible of the regulation of glucose uptake by mediating insulininduced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at Ser21 and GSK3B at Ser9, resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signalrelated kinase). - Proteine/Peptide
