Human ALK-1 / ACVRL1 Protein, His Tag (MALS verified), Unconjugated
Biozol Catalog Number:
ABS-AL1-H5228-1MG
Supplier Catalog Number:
AL1-H5228-1mg
Alternative Catalog Number:
ABS-AL1-H5228-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Serine/threonineprotein kinase receptor R3 is an enzyme that in humans is encoded by the ALK1 gene. ALK1 is a receptor in the TGF beta signaling pathway. ALK1 protein is a receptor in the TGF beta signaling pathway. It plays an important role in vascular development, remodeling, and pathologic angiogenesis, play a role in stabilizing angiogenic vessels and contribute to resistance to antiVEGF therapies, ALK1 blockade may represent an effective therapeutic opportunity complementary to the current antiangiogenic modalities in the clinic. Recently, researcher found that, ALK1Fc inhibited BMP9mediated Id1 expression in human umbilical vein endothelial cells and inhibited cord formation by these cells on a Matrigel substrate, in a chick chorioallantoic membrane assay, ALK1Fc reduced vascular endothelial growth factor, fibroblast growth factor, and BMP10mediated vessel formation, and ALK1Fc treatment reduced tumor burden in mice receiving orthotopic grafts of MCF7 mammary adenocarcinoma cells. - Proteine/Peptide
