Human Angiotensinogen Protein, His Tag (MALS verified), Unconjugated
Biozol Catalog Number:
ABS-ANN-H5243-100UG
Supplier Catalog Number:
ANN-H5243-100ug
Alternative Catalog Number:
ABS-ANN-H5243-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
The protein encoded by this gene, preangiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with nonfamilial structural atrial fibrillation, and inflammatory bowel disease. - Proteine/Peptide
