Human beta 2-Microglobulin / B2M Protein, His Tag, Unconjugated
Biozol Catalog Number:
ABS-B2M-H5225-1MG
Supplier Catalog Number:
B2M-H5225-1mg
Alternative Catalog Number:
ABS-B2M-H5225-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
beta2 microglobulin is also known as Beta2microglobulin (B2M), is a component of MHC class I molecules which belongs to the beta2microglobulin family. B2M is present on all nucleated cells (excludes red blood cells). B2M associates not only with the alpha chain of MHC class I molecules, but also with class Ilike molecules such as CD1 and Qa. An additional function of B2M is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis. Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP). - Proteine/Peptide
