Human B7-H6 / NCR3LG1 Protein, His Tag (MALS verified), Unconjugated
Biozol Catalog Number:
ABS-B76-H52H8-100UG
Supplier Catalog Number:
B76-H52H8-100ug
Alternative Catalog Number:
ABS-B76-H52H8-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene, however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) Tcell therapies have demonstrated durable and potentially curative therapeutic efficacy against Bcell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues. - Proteine/Peptide
