Human B7-H7 / HHLA2 Protein, His Tag, low endotoxin (MALS verified), Unconjugated
Biozol Catalog Number:
ABS-B77-H52H6-1MG
Supplier Catalog Number:
B77-H52H6-1mg
Alternative Catalog Number:
ABS-B77-H52H6-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
B7H7 (HHLA2) is a newly identified B7 family member that regulates human Tcell functions. B7H7 was previously known as human endogenous retrovirusH long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7H7 has been identified as a specific ligand for human CD28H. The B7H7CD28H pathway strongly promoted CD4+ Tcell proliferation and cytokine production via an AKTdependent signaling cascade in the presence of TCR signaling, suggesting B7H7 comprises a new costimulatory pathway. The first IgV domain of B7H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members. - Proteine/Peptide
Immobilized Human CD28H, Fc Tag (Cat. No. CDH-H5251) at 5 µg/mL (100 µL/well) can bind Human B7-H7, His Tag (Cat. No. B77-H52H6) with a linear range of 0.078-2.5 µg/mL (QC tested).
Immobilized Human B7-H7, His Tag (Cat. No. B77-H52H6) at 5 µg/mL (100 µL/well) can bind Human CD28H, Fc Tag (Cat. No. CDH-H5251) with a linear range of 10-156 ng/mL (Routinely tested).
Human B7-H7, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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