Betasecretase 1 (BACE1) is also known as betasite APP cleaving enzyme 1 (betasite amyloid precursor protein cleaving enzyme 1), memapsin2 (membraneassociated aspartic protease 2), and aspartyl protease 2 (ASP2), betaSecretase , and is a member of the peptidase A1 protein family, BACE1 is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. BACE1 is an asparticacid protease important in the pathogenesis of Alzheimers disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP). Generation of the 40 or 42 amino acidlong amyloidbeta peptides that aggregate in the brain of Alzheimers patients requires two sequential cleavages of the APP. Extracellular cleavage of APP by BACE creates a soluble extracellular fragment and a cell membranebound fragment referred to as C99. The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positivefeedback loop in AD. - Proteine/Peptide
