Human BAFF & APRIL Heterotrimer Protein, His Tag (MALS verified), Unconjugated
Biozol Catalog Number:
ABS-BAL-H5243-100UG
Supplier Catalog Number:
BAL-H5243-100ug
Alternative Catalog Number:
ABS-BAL-H5243-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
BAFF and APRIL are two members of the TNF superfamily that are secreted by activated myeloid cells and have costimulatory activity on B cells. BAFF/APRIL signaling regulates a diverse range of biological processes, including cell differentiation, proliferation, survival, and effector functions. Dysregulation of the BAFF/APRIL system has been linked to several inflammatory conditions, specifically autoimmune diseases. Elevated levels of BAFF and APRIL have been reported in autoimmune SLE patients. Both BAFF and APRIL have been described as homotrimeric molecules, a feature common to members of the TNF superfamily. But APRIL and BAFF can form active heterotrimer molecules when coexpressed, and circulating heterotrimer exists in serum samples of patients with systemic immune rheumatic diseases. These findings increase the possibility that the active BAFF/APRIL heterotrimer may play a role in rheumatic diseases and other autoimmune diseases. - Proteine/Peptide
Immobilized Human BCMA, Fc Tag, premium grade (Cat. No. BC7-H5254) at 5 µg/mL (100 µL/well) can bind Human BAFF & APRIL Heterotrimer Protein, His Tag (Cat. No. BAL-H5243) with a linear range of 0.016-0.125 µg/mL (QC tested).
Immobilized Human BCMA, Mouse IgG2a Fc Tag (Cat. No. BCA-H5253) at 5 µg/mL (100 µL/well) can bind Human BAFF & APRIL Heterotrimer Protein, His Tag (Cat. No. BAL-H5243) with a linear range of 0.016-0.125 µg/mL (Routinely tested).
Human BAFF & APRIL Heterotrimer Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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