Human FGF basic Protein, premium grade, Unconjugated, E. coli
Biozol Catalog Number:
ABS-BFF-H4117-20UG
Supplier Catalog Number:
BFF-H4117-20ug
Alternative Catalog Number:
ABS-BFF-H4117-20UG
Manufacturer:
AcroBiosystems
Host:
E. coli
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
FGF basic is a member of the FGF family of at least 23 related mitogenic proteins which show 3560% amino acid conservation. FGF acidic and basic, unlike the other members of the family, lack signal peptides and are apparently secreted by mechanisms other than the classical protein secretion pathway. FGF basic has been isolated from a number of sources, including neural tissue, pituitary, adrenal cortex, corpus luteum, and placenta. This factor contains four cysteine residues, but reduced FGF basic retains full biological activity, indicating that disulfide bonds are not required for this activity. bFGF is a critical component of human embryonic stem cell culture medium, the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. It has been demonstrated to induce gremlin expression which in turn is known to inhibit the induction of differentiation by bone morphogenetic proteins. It is necessary in mousefeeder cell dependent culture systems, as well as in feeder and serumfree culture systems. - Proteine/Peptide
