Human CCR10 Full Length Protein (VLP), Unconjugated
Biozol Catalog Number:
ABS-CC0-H52P3-100UG
Supplier Catalog Number:
CC0-H52P3-100ug
Alternative Catalog Number:
ABS-CC0-H52P3-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Chemokines and chemokine receptors regulate tissuespecific migration, maintenance and functions of immune cells. Among them, chemokine receptor CCR10 and its ligands chemokines CCL27 and CCL28 are uniquely involved in the epithelial immunity. CCL27 is expressed predominantly in the skin by keratinocytes while CCL28 is expressed by epithelial cells of various mucosal tissues. CCR10 is expressed by various subsets of innatelike T cells that are programmed to localize to the skin during their developmental processes in the thymus. Circulating T cells might be imprinted by skinassociated antigenpresenting cells to express CCR10 for their recruitment to the skin during the local immune response. On the other hand, IgA antibodyproducing B cells generated in mucosaassociated lymphoid tissues express CCR10 for their migration and maintenance at mucosal sites. Increasing evidence also found that CCR10/ligands are involved in regulation of other immune cells in epithelial immunity and are frequently exploited by epitheliumlocalizing or originated cancer cells for their survival, proliferation and evasion from immune surveillance. - Proteine/Peptide
