Human CCL21 Protein, His Tag, Unconjugated, Insect
Biozol Catalog Number:
ABS-CC1-H55H3-1MG
Supplier Catalog Number:
CC1-H55H3-1mg
Alternative Catalog Number:
ABS-CC1-H55H3-1MG
Manufacturer:
AcroBiosystems
Host:
Insect
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
CC chemokine 21 (CCL21), also known as secondary lymphoidorgan chemokine (SLC), is a ligand for the chemokine receptor CCR7. CCL19 and CCL21 are the only ligands for CCR7, which is expressed by various subsets of immune cells. CCL19 and CCL21 function to recruit CCR7 expressing antigen presenting cells, like dendritic cells and naive Tcells, to the lymph nodes. CCL21 seems to be the critical CCR7 ligand regulating dendritic cell homeostasis and function. CCL21 has an unusual extended Cterminal tail for a chemokine. Only one gene exists for this chemokine in human beings, whereas mice have two. CCL21 Inhibit hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated Tcells, but not for Bcells, macrophages, or neutrophils. Shows preferential activity towards naive Tcells. - Proteine/Peptide
