Rhesus macaque CCR8 Full Length Protein (VLP), Unconjugated, Human
Biozol Catalog Number:
ABS-CC8-R52P3-500UG
Supplier Catalog Number:
CC8-R52P3-500ug
Alternative Catalog Number:
ABS-CC8-R52P3-500UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Monkey
Conjugation:
Unconjugated
CCR8 is a key chemokine receptor primarily expressed on regulatory T cells (Tregs) infiltrating the tumor microenvironment. It plays a decisive role in mediating immunosuppression by facilitating Treg recruitment and activation. Emerging research highlights the interaction between CCR8 and glycosaminoglycans (GAGs), which serve as essential coreceptors. GAGs facilitate the presentation of ligands like CCL1 to CCR8, effectively concentrating chemokines on the cell surface to enhance signaling efficiency. Targeting the CCR8GAG axis represents a sophisticated strategy for selective Treg depletion, offering high precision for cancer immunotherapy while minimizing systemic autoimmune side effects. - Proteine/Peptide
