Human CD31 / PECAM-1 Protein, His Tag, Unconjugated

Product Overview

• Article Name: Human CD31 / PECAM-1 Protein, His Tag, Unconjugated
• Biozol Catalog Number: ABS-CD1-H5224-1MG
• Supplier Catalog Number: CD1-H5224-1mg
• Alternative Catalog Number: ABS-CD1-H5224-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Cluster of Differentiation 31 (CD31) is also known as Platelet endothelial cell adhesion molecule (PECAM1), is a 130kDa transmembrane glycoprotein expressed by endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, osteoclasts, neutrophils, certain tumors, and is the only known member of the CAM family on platelets. CD31 is found on the surface of platelets, monocytes, neutrophils, and some types of Tcells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. CD31 plays a key role in removing aged neutrophils from the body. CD31 mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin alphavbeta3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development. In addition, it has been shown that CD31 expression is upregulated by LPS stimulation, and might function as a feedback negative regulator of LPS inflammatory response in macrophages. - Proteine/Peptide

Product Properties

• Molecular Weight: 66.4 kDa
• Tag: C-10*His
• NCBI: 16284
• Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
• Purity: 95%
• Form: Powder
• Target: CD31

Images

Human CD31, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.