Human Siglec-3 / CD33 Protein, His Tag (MALS verified), Unconjugated

Product Overview

• Article Name: Human Siglec-3 / CD33 Protein, His Tag (MALS verified), Unconjugated
• Biozol Catalog Number: ABS-CD3-H5226-1MG
• Supplier Catalog Number: CD3-H5226-1mg
• Alternative Catalog Number: ABS-CD3-H5226-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Iglike lectins) and GP67, is a singlepass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Iglike lectin) family. Human CD33 / Siglec3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an Nterminal Iglike Vtype domain, one Iglike C2type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec3 usually considered myeloidspecific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec3 induces apoptosis in acute myeloid leukemia. - Proteine/Peptide

Product Properties

• Molecular Weight: 27.6 kDa
• Tag: C-6*His
• NCBI: 28152
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: Siglec-3

Images

CD3-H5226-1mg

Immobilized Anti-Human CD33 MAb, Mouse IgG1 at 1 µg/mL (100 µL/well) can bind Human Siglec-3, His Tag (Cat. No. CD3-H5226) with a linear range of 0.1-2 ng/mL (QC tested).

Immobilized Human Siglec-3, His Tag (Cat. No. CD3-H5226) at 1 µg/mL (100 µL/well) can bind Lintuzumab with a linear range of 0.06-1 ng/mL (Routinely tested).

Human Siglec-3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.