Biotinylated Human Siglec-3 / CD33 Protein, Fc,Avitag(TM) (MALS verified)
Biozol Catalog Number:
ABS-CD3-H82F3-25UG
Supplier Catalog Number:
CD3-H82F3-25ug
Alternative Catalog Number:
ABS-CD3-H82F3-25UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Biotin
Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Iglike lectins) and GP67, is a singlepass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Iglike lectin) family. Human CD33 / Siglec3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an Nterminal Iglike Vtype domain, one Iglike C2type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec3 usually considered myeloidspecific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec3 induces apoptosis in acute myeloid leukemia. - Proteine/Peptide
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Purity:
95%
Form:
Powder
Target:
Siglec-3
Immobilized Biotinylated Human Siglec-3,Fc,Avitag (Cat. No. CD3-H82F3) at 1 µg/mL (100 µL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 µg/well) plate can bind Anti-Siglec-3 Antibody, Human IgG1 with a linear range of 0.2-2 ng/mL (QC tested).
Biotinylated Human Siglec-3,Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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