Human CD36 / SR-B3 Protein, His Tag (MALS verified), Unconjugated

Product Overview

• Article Name: Human CD36 / SR-B3 Protein, His Tag (MALS verified), Unconjugated
• Biozol Catalog Number: ABS-CD6-H5221-100UG
• Supplier Catalog Number: CD6-H5221-100ug
• Alternative Catalog Number: ABS-CD6-H5221-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

CD36 (Cluster of Differentiation 36) is also known as platelet membrane glycoprotein IV (GPIV), fatty acid translocase (FAT), thrombospondin receptor, collagen receptor, and scavenger receptor class B, member 3 (SRB3), is a member of the class B scavenger receptor family of cell surface proteins. The human CD36 gene encodes a single chain 472 amino acid residue protein containing both an N and a Cterminal cytoplasmic tail and an extracellular loop.CD36 is found on platelets, erythrocytes, monocytes, differentiated adipocytes, mammary epithelial cells, spleen cells and some skin microdermal endothelial cells. CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands, including long chain fatty acid (LCFA), advanced glycation end products (AGE), thrombospondin1, oxidized lowdensity lipoproteins (oxLDLs), high density lipoprotein (HDL), phosphatidylserine, apoptotic cells, betaamyloid fibrils (fAbeta), collagens I and IV, and Plasmodium falciparum infected erythrocytes. CD36 is required for the antiangiogenic effects of thrombospondin1 In the corneal neovascularization assay. On binding a ligand the protein and ligand are internalized. This internalization is independent of macropinocytosis and occurs by an actin dependent mechanism requiring the activation Srcfamily kinases, JNK and Rhofamily GTPases. CD36 ligands have also been shown to promote sterile inflammation through assembly of a Tolllike receptor 4 and 6 heterodimer. - Proteine/Peptide

Product Properties

• Molecular Weight: 48.5 kDa
• Tag: C-10*His
• NCBI: 001001547
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: CD36

Images

Immobilized Mouse/IgG1,CD36 Antibody at 1 µg/mL (100 µL/well) can bind Human CD36, His Tag (Cat. No. CD6-H5221) with a linear range of 1-16 ng/mL (QC tested).

Immobilized Human CD36, His Tag (Cat. No. CD6-H5221) at 1 µg/mL (100 µL/well) can bind Mouse/IgG1,CD36 Antibody with a linear range of 0.1-6 ng/mL (Routinely tested).

Human CD36, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.