Human CD46 Protein, His Tag (MALS verified), Unconjugated

Product Overview

• Article Name: Human CD46 Protein, His Tag (MALS verified), Unconjugated
• Biozol Catalog Number: ABS-CD6-H5226-50UG
• Supplier Catalog Number: CD6-H5226-50ug
• Alternative Catalog Number: ABS-CD6-H5226-50UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complementmediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for Tcells which induces the differentiation of CD4+ into Tregulatory 1 cells. In Tcells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2). - Proteine/Peptide

Product Properties

• Molecular Weight: 33.6 kDa
• Tag: C-6*His
• NCBI: 15529
• Buffer: PBS, pH7.4
• Purity: 90%
• Form: Powder
• Target: CD46

Images

Immobilized Human CD46, His Tag (Cat. No. CD6-H5226) at 1 µg/mL (100 µL/well) can bind FG-3246 (FOR46), Human IgG1 kappa with a linear range of 0.3-2 ng/mL (QC tested).

Human CD46, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.