Biotinylated Human IL-6 R alpha / CD126 Protein, Avitag(TM),His Tag (MALS verified)
Biozol Catalog Number:
ABS-CD6-H82E8-25UG
Supplier Catalog Number:
CD6-H82E8-25ug
Alternative Catalog Number:
ABS-CD6-H82E8-25UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Biotin
Interleukin 6 receptor (IL6R) is also known as CD126 (Cluster of Differentiation 126) , is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL6R is a protein complex consisting of a IL6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported. IL6R subunit also shared by many other cytokines. The soluble form of IL6R arises from proteolytic cleavage of membranebound IL6Ralpha, and acts agonistically by making the IL6 ligand accessible to the signal transducer gp130. Dysregulated production of IL6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis, and it has been reported that a humanized antiIL6R monoclonal antibody is a promising agent applicable to the therapeutic approach for IL6 driven diseases. Interleukin6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor. - Proteine/Peptide
Immobilized Human IL-6, premium grade (Cat. No. IL6-H4218) at 5 µg/mL (100 µL/well) can bind Biotinylated Human IL-6 R alpha, Avitag,His Tag (Cat. No. CD6-H82E8) with a linear range of 4-63 ng/mL (QC tested).
Biotinylated Human IL-6 R alpha, Avitag,His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
* VAT and and shipping costs not included. Errors and price changes excepted
