Biotinylated Human CD6 / TP120 Protein, Fc,Avitag(TM) (MALS verified)
Biozol Catalog Number:
ABS-CD6-H82F3-25UG
Supplier Catalog Number:
CD6-H82F3-25ug
Alternative Catalog Number:
ABS-CD6-H82F3-25UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Biotin
CD6 is a type 1 transmembrane glycoprotein with three extracellular SRCR domains that functions as a costimulatory receptor in T cell activation. Its primary ligand is CD166 (ALCAM), an IgSF member expressed on antigenpresenting cells and other tissues. CD6s long cytoplasmic tail contains tyrosine residues that, upon phosphorylation, recruit signaling molecules like SLP76 and SHP1. The CD6ALCAM interaction promotes T cell activation and downstream MAPK signaling, influencing proliferation, differentiation, and survival. Importantly, CD6 regulates effector T cell (Teff) activity and trafficking, making it a key checkpoint in autoimmunity. Blocking the CD6ALCAM pathway selectively inhibits pathogenic Teff cells while preserving Treg function, offering a potential therapeutic strategy for autoimmune diseases. - Proteine/Peptide
Immobilized Human ALCAM, His Tag (Cat. No. CD6-H5228) at 5 µg/mL (100 µL/well) can bind Biotinylated Human CD6 Protein, Fc,Avitag (Cat. No. CD6-H82F3) with a linear range of 0.01-0.313 µg/mL (QC tested).
Biotinylated Human CD6 Protein, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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