Mouse B7-2 / CD86 Protein, Fc Tag (MALS verified), Unconjugated, Human

Product Overview

• Article Name: Mouse B7-2 / CD86 Protein, Fc Tag (MALS verified), Unconjugated, Human
• Biozol Catalog Number: ABS-CD6-M5251-100UG
• Supplier Catalog Number: CD6-M5251-100ug
• Alternative Catalog Number: ABS-CD6-M5251-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Mouse
• Conjugation: Unconjugated

Product Description

Cluster of Differentiation 86 (CD86) is also known as Blymphocyte activation antigen B72, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon gamma. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B72 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NFkappaBsignaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstlinetherapy. - Proteine/Peptide

Product Properties

• Molecular Weight: 51.9 kDa
• Tag: C-Fc
• NCBI: 062261
• Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Purity: 95%
• Form: Powder
• Target: B7-2

Images

Immobilized Mouse B7-2, Fc Tag (Cat. No. CD6-M5251) at 5 µg/mL (100 µL/well) can bind Mouse CTLA-4, His Tag (Cat. No. CT4-M52H5) with a linear range of 0.4-13 ng/mL (QC tested).

Immobilized Biotinylated Mouse CD28, His,Avitag (Cat. No. CD8-M82E3) at 1 µg/mL (100 µL/well) on Streptavidin (Cat. No. STN-N5116) precoated (0.5 µg/well) plate, can bind Mouse B7-2, Fc Tag (Cat. No. CD6-M5251) with a linear range of 2-39 ng/mL (Routinely tested).

Mouse B7-2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.